Designation/Position- Postdoctoral Research Fellow
About- Ryerson University is at the intersection of mind and action. What our students learn in the classroom is enhanced by real-world knowledge and experience. We champion diversity, entrepreneurship and innovation.
Research/Job area– Chemistry and Biology
Location- Ryerson University, Canada
- A PhD in a relevant discipline (e.g. cell biology, cancer biology, molecular genetics, biochemistry, metabolism).
- Experience with fluorescence microscopy would be an important asset.
- Experience with image analysis methods, including methods to study large datasets would be an asset.
- Experience with at least one of cellular signaling, cell metabolism, cancer biology and/or cancer therapeutics would be useful to the applicant.
- Willingness to work in an interdisciplinary setting.
Job/Position Description- Research group welcome applications for a full-time postdoctoral fellow, working within the Department of Chemistry and Biology at Ryerson University. The successful candidate will be primarily supervised by Drs. Costin Antonescu and Roberto Botelho and be positioned in the new, state-of-the-art Ryerson biomedical research facilities in the MaRS tower in downtown Toronto. The successful candidate will lead a project to study how cell metabolism governs cell differentiation and tumor progression. This project is funded for a minimum of 2 years, with support from Ryerson University and the Canadian Institutes of Health Research (CIHR).
Altered cell metabolism is a critical hallmark of cancer and control of metabolism is emerging as an important regulator of development and cellular differentiation. Importantly, even largely isogenic cancer cells exhibit remarkable metabolic heterogeneity, a phenomenon that is also seen in normal cells. How the distinct metabolism of individual cells in a population dictates the response of these cells to oncogenes, differentiation factors, or anti-cancer drugs is an exciting question that when answered may reveal key clues for improved cancer treatment. The project led by the successful applicant will develop and use a variety of fluorescent biosensors to establish the metabolic profile of individual cells and examine how the unique metabolic profile of individual cells controls cell outcomes relevant to cancer, including growth and proliferation, invasiveness, migration and drug response. This project will also allow study of the related phenomenon of how the metabolic profile of individual embryonic stem cells dictates differentiation and self-renewal outcomes.
The successful applicant will be a member of Dr. Antonescu’s and Dr. Botelho’s research teams and also have the opportunity to work closely with other researchers in the Department, including Drs. Sarah Sabatinos and Gagan Gupta. The Antonescu cancer cell biology lab spans the study of fundamental to translational and seeks to understand how the dynamic multiscale organization of signaling hubs and membrane compartments within cells is regulated by cues such as growth factors and metabolism. In turn, we study how these phenomena control cellular outcomes such as growth and drug response, and how they can be exploited therapeutically such as for the purpose of drug delivery or biomarker development. The Botelho lab studies the regulation and adaptation of organelles, in particular in the context of immunity. Our groups specialize in the use of advanced fluorescence microscopy techniques, many of which are available in-house, coupled to custom automated image analysis.
The successful applicant will be responsible for various aspects of project design, completing experiments, data analysis, data storage and safeguard, manuscript preparation, grant writing and presentation of results at conferences. The successful candidate will also be given opportunities to supervise and mentor graduate students.
Salary and benefits will be commensurate with experience.
Salary range is $35,000 – $50,000 a year plus benefits. The position is for two years with the possibility of extension.
Expected start date: May 1st, 2018 or as soon as possible
How to apply- Apply online before: Friday May 4, 2018 (4:30pm)